Blood glucose and ECG variables at baseline , at blood glucose nadir and 90 minutes after blood glucose nadir. Table 2. Estimated changes in ECG variables over time with as reference point.
Estimates are based on a statistical model fit to each variable. Table 3. Figure 2. The two ECGs are from left side and at right side at the same episode. Figure 3. Figure 4. The QT interval is measured using the manual annotation MA method. References R. Tattersall and G. View at: Google Scholar R.
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Corresponding author. Received Jan 15; Accepted May Published on behalf of the American Heart Association, Inc.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
This article has been corrected. See J Am Heart Assoc. This article has been cited by other articles in PMC. Abstract Background Drug safety precautions recommend monitoring of the corrected QT interval.
Keywords: electrocardiography, mortality, population, QT interval electrocardiography, risk factors, risk prediction. Introduction The QT interval is a measure of the duration of ventricular repolarization. Patients were selected to fulfill the following criteria: No cardiovascular medical history No significant medical history, such as diabetes mellitus, chronic obstructive pulmonary disease, etc.
Results Demographics A total of patients were included in the analysis. Table 1 Demographics. Open in a separate window. Figure 1.
Figure 2. Table 6 Reference Interval by Sex. Mortality Analysis In total, 0. Reference Interval The determined LLN within the healthy subpopulation corresponded to the proposed lower limit of ms, with a maximal variation of only 6 ms for both men and women for all QT correction formulae studied. Conclusion The current use of Bazett's QT correction formula in clinical standards should be questioned.
Supporting information Table S1. Notes J Am Heart Assoc. References 1. Garson A Jr. How to measure the QT interval—what is normal? Am J Cardiol. Br J Clin Pharmacol. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation.
Atypical antipsychotic drugs and the risk of sudden cardiac death. N Engl J Med. Ann Noninvasive Electrocardiol. QT interval prolongation predicts cardiovascular mortality in an apparently healthy population. Risk prediction of cardiovascular death based on the QTc interval: evaluating age and gender differences in a large primary care population.
Eur Heart J. Malik M. J Cardiovasc Electrophysiol. Bazett HC. Fridericia LS. Die systolendauer im elektrokardiogramm bei normalen menschen und bei herzkranken. Acta Med Scand. Bazett's QT correction reviewed: evidence that a linear QT correction for heart rate is better. J Am Coll Cardiol. Assessment of prolonged QT and JT intervals in ventricular conduction defects.
Med Sci Monit. Horowitz GL. Int J Clin Pharm. J Electrocardiol.
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